The Muscatine was a 322 ton side wheel steam vessel built at Wheeling, West Virginia in 1863 for the Northern Line Packet Company under the supervision of Captain Richard C. Gray. In the fall of 1866 between 200 and 500 barrels of apples were put off from the Muscatine in an upriver port.
The Muscatine was stranded and lost in the Black River at North LaCrosse in 1880. She was dismantled at LaCrosse in 1881.

"The Muscatine was wrecked from age in Black river, near Davidson's yard." La Crosse Daily Press July 15, 1901